AML free registry Cleaner. - Best free registry cleaner imo.
CCleaner - Deletes temporary files/crap you pick up from the internetz, also has a registry cleaner and backup function.
ATF cleaner - Does the same thing as CCleaner, just an alternative.
Other free and good antispyware/antivirus (apart from adaware and AVG, which are very good);
Malwarebytes' Anti-Malware
AntiVir PE Classic
Spybot - Search & Destroy
SUPERAntiSpyware Free Edition
Hijack this - Registry prober and patcher, wouldn't recommend it for a novice, but it can be useful.
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