Yeah, I should have been more specific: exit windows and go to dos then run the command line. Within windows, the file is being run from the ram. I have done this a few times in the past. It is more secure in the sense that most recent viruses run within windows.
[though there is a couple of old viruses called pacman and cascade, they would run within dos through the ram and delete the whole hard drive, beginning with their own system file, effectively deleting themselves first - no trace. What happened was you had either pacman going across your screen eating whatever is in front or the contents of your desktop falling to the bottom of the screen. While you're being mesmerized, your hard drive empties itself and the only solution is to pull the plug and do some damage limitation]
and it actually formats the drive. As opposed to a reinstall windows which does not actually erase everything, only reinstalling what isn't there (I'm saying this since Zbot creates command lines within win32 then spreads to most system and administrator files, steals your passwords and creates remote trojans - 'tis a nasty little shit and my guess is OP opened a zip file through some spam email or downloaded from pirate sites). For instance try leaving a few files in your bin then do a full reinstall, the files will be there once you have completed the reinstall. This is why a format is safer because you could always have some root files left.
NB: before wiping it all out, make sure you have all your drivers and recovery discs, otherwise you're in for a headache
+ change all your passwords from another computer before yours is safe. The purpose of this virus is to steal your bank details.